Cardiac arrest is one of the biggest global health problems, and early identification and management are key to enhancing the patient's prognosis. In this paper, we propose a novel framework that combines an EfficientNet-based deep learning model with a digital twin system to improve the early detection and analysis of cardiac arrest. We use compound scaling and EfficientNet to learn the features of cardiovascular images. In parallel, the digital twin creates a realistic and individualized cardiovascular system model of the patient based on data received from the Internet of Things (IoT) devices attached to the patient, which can help in the constant assessment of the patient and the impact of possible treatment plans. As shown by our experiments, the proposed system is highly accurate in its prediction abilities and, at the same time, efficient. Combining highly advanced techniques such as deep learning and digital twin (DT) technology presents the possibility of using an active and individual approach to predicting cardiac disease.

4D Flow Magnetic Resonance Imaging (4D Flow MRI) is a non-invasive measurement technique capable of quantifying blood flow across the cardiovascular system. While practical use is limited by spatial resolution and image noise, incorporation of trained super-resolution (SR) networks has potential to enhance image quality post-scan. However, these efforts have predominantly been restricted to narrowly defined cardiovascular domains, with limited exploration of how SR performance extends across the cardiovascular system; a task aggravated by contrasting hemodynamic conditions apparent across the cardiovasculature. The aim of our study was to explore the generalizability of SR 4D Flow MRI using a combination of heterogeneous training sets and dedicated ensemble learning. With synthetic training data generated across three disparate domains (cardiac, aortic, cerebrovascular), varying convolutional base and ensemble learners were evaluated as a function of domain and architecture, quantifying performance on both in-silico and acquired in-vivo data from the same three domains. Results show that both bagging and stacking ensembling enhance SR performance across domains, accurately predicting high-resolution velocities from low-resolution input data in-silico. Likewise, optimized networks successfully recover native resolution velocities from downsampled in-vivo data, as well as show qualitative potential in generating denoised SR-images from clinical level input data. In conclusion, our work presents a viable approach for generalized SR 4D Flow MRI, with ensemble learning extending utility across various clinical areas of interest.

Scientific advancements in nanotechnology and advanced materials are paving the way toward nanoscale devices for in-body precision medicine; comprising integrated sensing, computing, communication, data and energy storage capabilities. In the human cardiovascular system, such devices are envisioned to be passively flowing and continuously sensing for detecting events of diagnostic interest. The diagnostic value of detecting such events can be enhanced by assigning to them their physical locations (e.g., body region), which is the main proposition of flow-guided localization. Current flow-guided localization approaches suffer from low localization accuracy and they are by-design unable to localize events within the entire cardiovascular system. Toward addressing this issue, we propose the utilization of Graph Neural Networks (GNNs) for this purpose, and demonstrate localization accuracy and coverage enhancements of our proposal over the existing State of the Art (SotA) approaches. Based on our evaluation, we provide several design guidelines for GNN-enabled flow-guided localization.

GE Healthcare has secured 510k clearance from the Food and Drug Administration (FDA) for its Ultra Edition package of Vivid cardiovascular ultrasound systems. The Vivid Ultra Edition includes new features based on artificial intelligence (AI) to enable clinicians to obtain quick and more repeatable exams with consistency. It delivers improved efficiency to the scanning process by providing reduced exam time through up to 80% fewer clicks, 99% accuracy and lower inter-operator variability. A methodical evaluation of heart function is considered vital in echocardiography while high-quality data acquisition and operator skills are important elements to obtain accurate and complete exams. Utilising AI-driven, neural network-based algorithms, Vivid Ultra Edition features enable repeatable and faster measurements in 2D echo imaging.

Inspired by the structure of the brain, artificial neural networks (ANN) are the answer to making computers more human like and help machines reason more like humans. They are based on the neural structure of the brain. The brain basically learns from experience. It is natural proof that some problems that are beyond the scope of current computers are indeed solvable by small energy efficient packages. To understand how artificial neural networks work let's first briefly look at the human ones. The exact workings of the human brain are still a mystery. Yet, some aspects of this amazing processor are known. In particular, the most basic element of the human brain is a specific type of cell which, unlike the rest of the body, doesn't appear to regenerate. Because this type of cell is the only part of the body that isn't slowly replaced, it is assumed that these cells are what provides us with our abilities to remember, think, and apply previous experiences to our every action.